|
KMID : 1140220220270030157
|
|
대한암예방학회지
2022 Volume.27 No. 3 p.157 ~ p.169
|
|
|
Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders
|
|
Lee Yeon-Hwa
Kim Su-Jung
Surh Young-Joon
|
|
|
Abstract
|
|
|
|
Silent mating type information regulator 2 homolog 1 (SIRT1), an NAD+-dependent histone/protein deacetylase, has multifarious physiological roles in development, metabolic regulation, and stress response. Thus, its abnormal expression or malfunction is implicated in pathogenesis of various diseases. SIRT1 undergoes post-translational modifications, including phosphorylation, oxidation/reduction, carbonylation, nitrosylation, glycosylation, ubiquitination/deubiquitination, SUMOylation etc. which can modulate its catalytic activity, stability, subcellular localization, and also binding affinity for substrate proteins. This short review highlights the regulation of SIRT1 post-translational modifications and their pathophysiologic implications.
|
|
|
KEYWORD
|
|
|
Post-translational modification, Protein processing, Sirtuin 1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|